{"id":8908,"date":"2025-05-31T10:59:03","date_gmt":"2025-05-31T01:59:03","guid":{"rendered":"https:\/\/kenkoubyouki.com\/?p=8908"},"modified":"2025-05-31T10:59:03","modified_gmt":"2025-05-31T01:59:03","slug":"post-8908","status":"publish","type":"post","link":"https:\/\/kenkoubyouki.com\/?p=8908","title":{"rendered":"\u304c\u3093\u3068\u8178\u5185\u7d30\u83cc\u53e2\uff1a\u6cbb\u7642\u53cd\u5fdc\u6027\u3068\u306e\u95a2\u9023\u6027"},"content":{"rendered":"

\u306f\u3058\u3081\u306b<\/span><\/h2>\n

\u304c\u3093\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e16\u754c\u7684\u306a\u6b7b\u56e0\u306e\u4e0a\u4f4d\u3092\u5360\u3081\u3066\u304a\u308a\u3001\u305d\u306e\u6cbb\u7642\u6cd5\u306f\u5e74\u3005\u9032\u6b69\u3057\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u4f9d\u7136\u3068\u3057\u3066\u6cbb\u7642\u52b9\u679c\u306b\u500b\u4eba\u5dee\u304c\u5b58\u5728\u3059\u308b\u3002\u8fd1\u5e74\u3001\u8178\u5185\u7d30\u83cc\u53e2\uff08\u30de\u30a4\u30af\u30ed\u30d0\u30a4\u30aa\u30fc\u30bf\uff09\u304c\u304c\u3093\u306e\u767a\u75c7\u3084\u6cbb\u7642\u53cd\u5fdc\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u8178\u5185\u7d30\u83cc\u306f\u514d\u75ab\u7cfb\u3001\u4ee3\u8b1d\u3001\u708e\u75c7\u53cd\u5fdc\u306a\u3069\u591a\u69d8\u306a\u751f\u7406\u6a5f\u80fd\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u69cb\u6210\u306e\u9055\u3044\u304c\u304c\u3093\u6cbb\u7642\u306e\u52b9\u679c\u3084\u526f\u4f5c\u7528\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u672c\u7a3f\u3067\u306f\u3001\u304c\u3093\u6cbb\u7642\u306b\u304a\u3051\u308b\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u3001\u6700\u65b0\u306e\u7814\u7a76\u3092\u57fa\u306b\u691c\u8a0e\u3059\u308b\u3002<\/span><\/p>\n

\u8178\u5185\u7d30\u83cc\u53e2\u3068\u306f<\/span><\/h2>\n

\u8178\u5185\u7d30\u83cc\u53e2\u306f\u4e3b\u306b\u5927\u8178\u306b\u5b58\u5728\u3059\u308b\u5fae\u751f\u7269\u306e\u96c6\u56e3\u3067\u3042\u308a\u3001\u30d2\u30c8\u306e\u5065\u5eb7\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3002\u4e3b\u306a\u69cb\u6210\u7d30\u83cc\u306fFirmicutes\u9580\u3001Bacteroidetes\u9580\u3001Actinobacteria\u9580\u3001Proteobacteria\u9580\u306a\u3069\u3067\u3042\u308b\u3002<\/span><\/p>\n

\u3053\u308c\u3089\u306e\u7d30\u83cc\u306f\u8178\u5185\u3067\u306e\u6804\u990a\u7d20\u306e\u4ee3\u8b1d\u3001\u30d3\u30bf\u30df\u30f3\u306e\u5408\u6210\u3001\u75c5\u539f\u83cc\u306e\u6392\u9664\u3001\u514d\u75ab\u6a5f\u80fd\u306e\u8abf\u7bc0\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u8178\u5185\u74b0\u5883\u306e\u4e71\u308c\uff08\u30c7\u30a3\u30b9\u30d0\u30a4\u30aa\u30fc\u30b7\u30b9\uff09\u306f\u708e\u75c7\u6027\u8178\u75be\u60a3\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u3055\u3089\u306b\u306f\u304c\u3093\u306e\u30ea\u30b9\u30af\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u8178\u5185\u7d30\u83cc\u53e2\u3068\u767a\u304c\u3093\u306e\u95a2\u9023\u6027<\/span><\/h2>\n

\u8178\u5185\u7d30\u83cc\u53e2\u306e\u69cb\u6210\u306f\u304c\u3093\u306e\u767a\u75c7\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u305f\u3068\u3048\u3070\u3001\u5927\u8178\u304c\u3093\u60a3\u8005\u306b\u304a\u3044\u3066\u306fFusobacterium nucleatum\u306e\u904e\u5270\u5897\u6b96\u304c\u89b3\u5bdf\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u3053\u308c\u306f\u708e\u75c7\u4fc3\u9032\u3084\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u56de\u907f\u3068\u3044\u3063\u305f\u767a\u304c\u3093\u904e\u7a0b\u3092\u4fc3\u9032\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u3068\u3055\u308c\u308b\u3002<\/span><\/p>\n

\u307e\u305f\u3001\u3042\u308b\u7a2e\u306e\u7d30\u83cc\uff08\u4f8b\uff1aEnterotoxigenic Bacteroides fragilis\uff09\u306f\u8178\u7ba1\u4e0a\u76ae\u306b\u6bd2\u7d20\u3092\u653e\u51fa\u3057\u3001DNA\u640d\u50b7\u3084\u7d30\u80de\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u5316\u306e\u4e00\u56e0\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u304c\u3093\u4e88\u9632\u3084\u8a3a\u65ad\u3078\u306e\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5fdc\u7528\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u8178\u5185\u7d30\u83cc\u53e2\u3068\u304c\u3093\u514d\u75ab\u7642\u6cd5<\/span><\/h2>\n

\u8fd1\u5e74\u6700\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u304c\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\uff08ICI\uff1aimmune checkpoint inhibitors\uff09\u306a\u3069\u306e\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u52b9\u679c\u306b\u95a2\u4e0e\u3059\u308b\u3068\u3044\u3046\u767a\u898b\u3067\u3042\u308b\u3002\u7279\u306b\u6297PD-1\u6297\u4f53\u3084\u6297CTLA-4\u6297\u4f53\u3068\u3044\u3063\u305f\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306e\u6cbb\u7642\u52b9\u679c\u306b\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306e\u69cb\u6210\u304c\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u3053\u3068\u304c\u30de\u30a6\u30b9\u304a\u3088\u3073\u30d2\u30c8\u306e\u7814\u7a76\u304b\u3089\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u4e3b\u306a\u7814\u7a76\u6210\u679c<\/span><\/h3>\n

2015\u5e74\u306eScience\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u6297PD-L1\u6297\u4f53\u306e\u52b9\u679c\u306f\u8178\u5185\u306b\u7279\u5b9a\u306e\u7d30\u83cc\uff08\u4f8b\uff1aBifidobacterium spp.\uff09\u304c\u5b58\u5728\u3059\u308b\u30de\u30a6\u30b9\u3067\u9855\u8457\u306b\u9ad8\u307e\u308a\u3001\u3053\u308c\u3089\u306e\u7d30\u83cc\u304c\u6a39\u72b6\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u6297\u816b\u760dT\u7d30\u80de\u5fdc\u7b54\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/p>\n

\u3055\u3089\u306b\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306b\u826f\u597d\u306a\u53cd\u5fdc\u3092\u793a\u3059\u60a3\u8005\u306f\u3001\u8178\u5185\u7d30\u83cc\u53e2\u306b\u304a\u3044\u3066Faecalibacterium\u5c5e\u3084Akkermansia muciniphila\u306e\u5b58\u5728\u6bd4\u304c\u9ad8\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u7d30\u83cc\u306f\u6297\u708e\u75c7\u4f5c\u7528\u3084\u8178\u7ba1\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u9069\u6b63\u5316\u3092\u901a\u3058\u3066\u6cbb\u7642\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u8178\u5185\u7d30\u83cc\u53e2\u306e\u64cd\u4f5c\u306b\u3088\u308b\u6cbb\u7642\u53cd\u5fdc\u6027\u306e\u5411\u4e0a<\/span><\/h2>\n

\u8178\u5185\u7d30\u83cc\u53e2\u306e\u69cb\u6210\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u304c\u3093\u6cbb\u7642\u306e\u52b9\u679c\u3092\u5411\u4e0a\u3055\u305b\u308b\u8a66\u307f\u304c\u306a\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u624b\u6cd5\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308b\uff1a<\/span><\/p>\n

1. \u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u304a\u3088\u3073\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9<\/span><\/h3>\n

\u5584\u7389\u83cc\uff08\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff09\u3084\u305d\u308c\u3092\u5897\u3084\u3059\u6804\u990a\u6e90\uff08\u30d7\u30ec\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\uff09\u306e\u6442\u53d6\u306b\u3088\u308a\u3001\u8178\u5185\u74b0\u5883\u3092\u6539\u5584\u3057\u3001\u514d\u75ab\u6a5f\u80fd\u3092\u5f37\u5316\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3002\u4f8b\u3048\u3070\u3001Lactobacillus\u5c5e\u3084Bifidobacterium\u5c5e\u306e\u88dc\u7d66\u306f\u3001T\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u816b\u760d\u514d\u75ab\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u52d5\u7269\u5b9f\u9a13\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

2. \u7cde\u4fbf\u5fae\u751f\u7269\u79fb\u690d\uff08FMT\uff09<\/span><\/h3>\n

\u8178\u5185\u7d30\u83cc\u53e2\u304c\u6b63\u5e38\u306a\u30c9\u30ca\u30fc\u306e\u7cde\u4fbf\u3092\u4ecb\u3057\u3066\u60a3\u8005\u306b\u79fb\u690d\u3055\u308c\u308b\u624b\u6cd5\u3002\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306b\u53cd\u5fdc\u3057\u306a\u3044\u304c\u3093\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001FMT\u306b\u3088\u308a\u6cbb\u7642\u52b9\u679c\u304c\u56de\u5fa9\u3059\u308b\u75c7\u4f8b\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u7279\u306bAkkermansia muciniphila\u3092\u542b\u3080\u30c9\u30ca\u30fc\u7531\u6765\u306eFMT\u304c\u6709\u52b9\u3067\u3042\u3063\u305f\u3068\u3059\u308b\u5831\u544a\u3082\u3042\u308b\u3002<\/span><\/p>\n

3. \u98df\u4e8b\u7642\u6cd5<\/span><\/h3>\n

\u8178\u5185\u7d30\u83cc\u53e2\u306f\u98df\u4e8b\u5185\u5bb9\u306b\u5f37\u304f\u5f71\u97ff\u3055\u308c\u308b\u305f\u3081\u3001\u98df\u7269\u7e4a\u7dad\u306e\u8c4a\u5bcc\u306a\u98df\u4e8b\u3001\u767a\u9175\u98df\u54c1\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u542b\u6709\u98df\u54c1\u306a\u3069\u304c\u8178\u5185\u74b0\u5883\u306e\u6539\u5584\u306b\u6709\u7528\u3068\u3055\u308c\u308b\u3002\u9ad8\u7e4a\u7dad\u98df\u306f\u3001\u77ed\u9396\u8102\u80aa\u9178\uff08SCFA\uff09\u3092\u7523\u751f\u3059\u308b\u7d30\u83cc\u306e\u5897\u52a0\u3092\u4fc3\u3057\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u901a\u3058\u3066\u816b\u760d\u5fae\u5c0f\u74b0\u5883\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002<\/span><\/p>\n

\u4eca\u5f8c\u306e\u8ab2\u984c\u3068\u5c55\u671b<\/span><\/h2>\n

\u8178\u5185\u7d30\u83cc\u53e2\u3092\u304c\u3093\u6cbb\u7642\u306b\u6d3b\u7528\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u8ab2\u984c\u304c\u6b8b\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

    \n
  • \n

    \u8178\u5185\u7d30\u83cc\u53e2\u306e\u500b\u4eba\u5dee\u304c\u5927\u304d\u304f\u3001\u7279\u5b9a\u306e\u7d30\u83cc\u306e\u52b9\u679c\u304c\u4e07\u4eba\u306b\u5f53\u3066\u306f\u307e\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u3002<\/span><\/p>\n<\/li>\n

  • \n

    FMT\u306e\u5b89\u5168\u6027\u3084\u6a19\u6e96\u5316\u3055\u308c\u305f\u30d7\u30ed\u30c8\u30b3\u30eb\u306e\u78ba\u7acb\u304c\u5fc5\u8981\u3002<\/span><\/p>\n<\/li>\n

  • \n

    \u8178\u5185\u7d30\u83cc\u304c\u6cbb\u7642\u53cd\u5fdc\u6027\u306b\u5f71\u97ff\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u304c\u4e0d\u5341\u5206\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n

    \u3057\u304b\u3057\u306a\u304c\u3089\u3001\u8178\u5185\u7d30\u83cc\u53e2\u3092\u6a19\u7684\u3068\u3057\u305f\u88dc\u5b8c\u7642\u6cd5\u306e\u53ef\u80fd\u6027\u306f\u5927\u304d\u304f\u3001\u4eca\u5f8c\u306e\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\uff08\u500b\u5225\u5316\u533b\u7642\uff09\u306e\u91cd\u8981\u306a\u4e00\u8981\u7d20\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

    \u7d50\u8ad6<\/span><\/h2>\n

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