{"id":8886,"date":"2025-05-30T22:11:35","date_gmt":"2025-05-30T13:11:35","guid":{"rendered":"https:\/\/kenkoubyouki.com\/?p=8886"},"modified":"2025-05-30T22:11:35","modified_gmt":"2025-05-30T13:11:35","slug":"post-8886","status":"publish","type":"post","link":"https:\/\/kenkoubyouki.com\/?p=8886","title":{"rendered":"\u904b\u52d5\u304c\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306b\u4e0e\u3048\u308b\u5f71\u97ff\uff1a\u30bb\u30ed\u30c8\u30cb\u30f3\u3068\u8133\u53ef\u5851\u6027\u306e\u8996\u70b9\u304b\u3089"},"content":{"rendered":"

\u306f\u3058\u3081\u306b<\/span><\/h2>\n

\u73fe\u4ee3\u793e\u4f1a\u306b\u304a\u3044\u3066\u3001\u3046\u3064\u75c5\u3084\u4e0d\u5b89\u969c\u5bb3\u3068\u3044\u3063\u305f\u7cbe\u795e\u75be\u60a3\u306e\u7f79\u60a3\u7387\u306f\u5e74\u3005\u5897\u52a0\u50be\u5411\u306b\u3042\u308a\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u7dad\u6301\u30fb\u5411\u4e0a\u306f\u91cd\u8981\u306a\u793e\u4f1a\u7684\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u305d\u306e\u5bfe\u7b56\u3068\u3057\u3066\u85ac\u7269\u7642\u6cd5\u3084\u8a8d\u77e5\u884c\u52d5\u7642\u6cd5\u304c\u4e00\u822c\u7684\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u8fd1\u5e74\u3067\u306f\u88dc\u5b8c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u904b\u52d5\u306e\u6709\u52b9\u6027\u304c\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u308b\u3002\u904b\u52d5\u306f\u8eab\u4f53\u7684\u5065\u5eb7\u306e\u5411\u4e0a\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u5fc3\u7406\u7684\u306a\u6069\u6075\u3082\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u591a\u6570\u306e\u7814\u7a76\u306b\u3088\u308a\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u672c\u7a3f\u3067\u306f\u3001\u904b\u52d5\u304c\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u3064\u3044\u3066\u3001\u300c\u30bb\u30ed\u30c8\u30cb\u30f3\u300d\u3068\u300c\u8133\u53ef\u5851\u6027\u300d\u3068\u3044\u30462\u3064\u306e\u795e\u7d4c\u79d1\u5b66\u7684\u306a\u8996\u70b9\u304b\u3089\u8003\u5bdf\u3059\u308b\u3002<\/span><\/p>\n

1. \u30bb\u30ed\u30c8\u30cb\u30f3\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9<\/span><\/h2>\n

1-1 \u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u57fa\u790e\u77e5\u8b58<\/span><\/h3>\n

\u30bb\u30ed\u30c8\u30cb\u30f3\uff085-\u30d2\u30c9\u30ed\u30ad\u30b7\u30c8\u30ea\u30d7\u30bf\u30df\u30f3\u30015-HT\uff09\u306f\u8133\u5185\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u4e00\u3064\u3067\u3001\u611f\u60c5\u3001\u7761\u7720\u3001\u98df\u6b32\u3001\u75db\u899a\u306a\u3069\u306e\u591a\u69d8\u306a\u751f\u7406\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u7279\u306b\u60c5\u52d5\u306e\u5236\u5fa1\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u304a\u308a\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u3046\u3064\u75c7\u72b6\u3084\u4e0d\u5b89\u306e\u5897\u52a0\u306b\u95a2\u9023\u3059\u308b\u3068\u3055\u308c\u308b\u3002<\/span><\/p>\n

1-2 \u904b\u52d5\u3068\u30bb\u30ed\u30c8\u30cb\u30f3\u5206\u6ccc<\/span><\/h3>\n

\u904b\u52d5\u304c\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5408\u6210\u3068\u5206\u6ccc\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306f\u52d5\u7269\u5b9f\u9a13\u304a\u3088\u3073\u30d2\u30c8\u306e\u7814\u7a76\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u6709\u9178\u7d20\u904b\u52d5\uff08\u4f8b\uff1a\u30b8\u30e7\u30ae\u30f3\u30b0\u3084\u30b5\u30a4\u30af\u30ea\u30f3\u30b0\uff09\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u524d\u99c6\u4f53\u3067\u3042\u308b\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u306e\u8133\u5185\u8f38\u9001\u3092\u5897\u52a0\u3055\u305b\u3001\u7d50\u679c\u7684\u306b\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u751f\u6210\u3092\u4fc3\u3059\u3002\u307e\u305f\u3001\u904b\u52d5\u306f\u30bb\u30ed\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53\u306e\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u52b9\u679c\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u4f8b\u3048\u3070\u3001\u7814\u7a76\u8005Meeusen\u3089\uff082006\uff09\u306f\u3001\u904b\u52d5\u5f8c\u306b\u8133\u5185\u306e\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u305d\u308c\u306b\u4f34\u3044\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u6d3b\u6027\u3082\u9ad8\u307e\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u904b\u52d5\u304c\u6c17\u5206\u3092\u9ad8\u63da\u3055\u305b\u3001\u6291\u3046\u3064\u611f\u60c5\u3092\u8efd\u6e1b\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u7aef\u3092\u8aac\u660e\u3059\u308b\u3002<\/span><\/p>\n

1-3 \u30bb\u30ed\u30c8\u30cb\u30f3\u3068\u7cbe\u795e\u75be\u60a3\u3078\u306e\u5f71\u97ff<\/span><\/h3>\n

\u3046\u3064\u75c5\u60a3\u8005\u306e\u591a\u304f\u306f\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u898b\u3089\u308c\u3001SSRI\uff08\u9078\u629e\u7684\u30bb\u30ed\u30c8\u30cb\u30f3\u518d\u53d6\u308a\u8fbc\u307f\u963b\u5bb3\u85ac\uff09\u306a\u3069\u304c\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u904b\u52d5\u304c\u30bb\u30ed\u30c8\u30cb\u30f3\u6d3b\u6027\u3092\u9ad8\u3081\u308b\u4f5c\u7528\u306f\u3001\u81ea\u7136\u306a\u6297\u3046\u3064\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u3068\u63a8\u5bdf\u3055\u308c\u308b\u3002<\/span><\/p>\n

\u904b\u52d5\u306b\u3088\u308b\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u5897\u52a0\u306f\u3001\u6162\u6027\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u308b\u611f\u60c5\u306e\u5909\u52d5\u3084\u4e0d\u5b89\u306e\u5236\u5fa1\u306b\u3082\u6709\u52b9\u3067\u3042\u308b\u3002\u5b9a\u671f\u7684\u306a\u904b\u52d5\u7fd2\u6163\u306f\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u6052\u5e38\u7684\u306a\u5206\u6ccc\u4fc3\u9032\u3092\u4fc3\u3057\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u4e88\u9632\u7684\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3002<\/span><\/p>\n

2. \u8133\u53ef\u5851\u6027\u3068\u904b\u52d5\u306e\u95a2\u4fc2<\/span><\/h2>\n

2-1 \u8133\u53ef\u5851\u6027\u3068\u306f\u4f55\u304b<\/span><\/h3>\n

\u8133\u53ef\u5851\u6027\uff08neuroplasticity\uff09\u3068\u306f\u3001\u8133\u304c\u7d4c\u9a13\u3084\u5b66\u7fd2\u306b\u3088\u3063\u3066\u69cb\u9020\u7684\u30fb\u6a5f\u80fd\u7684\u306b\u5909\u5316\u3059\u308b\u80fd\u529b\u3092\u6307\u3059\u3002\u3053\u308c\u306f\u795e\u7d4c\u56de\u8def\u306e\u518d\u7de8\u6210\u3001\u30b7\u30ca\u30d7\u30b9\u5f37\u5ea6\u306e\u5909\u5316\u3001\u65b0\u3057\u3044\u795e\u7d4c\u7d30\u80de\u306e\u751f\u6210\uff08\u795e\u7d4c\u65b0\u751f\uff09\u306a\u3069\u3092\u542b\u3080\u3002\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306b\u304a\u3044\u3066\u306f\u3001\u8133\u53ef\u5851\u6027\u306e\u4f4e\u4e0b\u304c\u3046\u3064\u75c5\u306a\u3069\u306e\u767a\u75c7\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

2-2 \u904b\u52d5\u3068\u795e\u7d4c\u65b0\u751f<\/span><\/h3>\n

\u7279\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u6d77\u99ac\uff08\u8a18\u61b6\u3084\u611f\u60c5\u306b\u95a2\u4e0e\u3059\u308b\u8133\u9818\u57df\uff09\u306b\u304a\u3051\u308b\u795e\u7d4c\u65b0\u751f\u3067\u3042\u308b\u3002\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u904b\u52d5\u306f\u8133\u7531\u6765\u795e\u7d4c\u6804\u990a\u56e0\u5b50\uff08BDNF\uff09\u306e\u5206\u6ccc\u3092\u4fc3\u9032\u3057\u3001\u3053\u308c\u304c\u795e\u7d4c\u65b0\u751f\u3084\u30b7\u30ca\u30d7\u30b9\u53ef\u5851\u6027\u3092\u9ad8\u3081\u308b\u3002BDNF\u306f\u300c\u8133\u306e\u80a5\u6599\u300d\u3068\u3082\u547c\u3070\u308c\u3001\u305d\u306e\u6fc3\u5ea6\u304c\u9ad8\u3044\u307b\u3069\u8a8d\u77e5\u6a5f\u80fd\u3084\u611f\u60c5\u8abf\u6574\u80fd\u529b\u304c\u5411\u4e0a\u3059\u308b\u3068\u3055\u308c\u308b\u3002<\/span><\/p>\n

Van Praag\u3089\uff081999\uff09\u306f\u3001\u904b\u52d5\u304c\u30de\u30a6\u30b9\u306e\u6d77\u99ac\u306b\u304a\u3044\u3066\u795e\u7d4c\u65b0\u751f\u3092\u9855\u8457\u306b\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u904b\u52d5\u304c\u5358\u306a\u308b\u8eab\u4f53\u7684\u6d3b\u52d5\u3067\u306f\u306a\u304f\u3001\u8133\u306e\u6a5f\u80fd\u305d\u306e\u3082\u306e\u3092\u5909\u5316\u3055\u305b\u3046\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002<\/span><\/p>\n

2-3 BDNF\u3068\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9<\/span><\/h3>\n

BDNF\u306e\u6fc3\u5ea6\u306f\u3046\u3064\u75c5\u60a3\u8005\u3067\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u6297\u3046\u3064\u85ac\u6295\u4e0e\u306b\u3088\u308a\u56de\u5fa9\u3059\u308b\u4f8b\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u904b\u52d5\u306b\u3088\u3063\u3066BDNF\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u6297\u3046\u3064\u4f5c\u7528\u3092\u6301\u3064\u975e\u85ac\u7269\u7684\u4ecb\u5165\u3068\u3057\u3066\u6709\u671b\u3067\u3042\u308b\u3002<\/span><\/p>\n

\u3055\u3089\u306b\u3001BDNF\u306f\u30bb\u30ed\u30c8\u30cb\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u4e21\u8005\u306f\u611f\u60c5\u5236\u5fa1\u306b\u304a\u3044\u3066\u88dc\u5b8c\u7684\u306b\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u904b\u52d5\u306b\u3088\u308bBDNF\u3068\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u540c\u6642\u6d3b\u6027\u5316\u306f\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306b\u304a\u3044\u3066\u76f8\u4e57\u7684\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/span><\/p>\n

3. \u904b\u52d5\u4ecb\u5165\u306b\u3088\u308b\u81e8\u5e8a\u7684\u52b9\u679c<\/span><\/h2>\n

3-1 \u3046\u3064\u75c5\u3078\u306e\u52b9\u679c<\/span><\/h3>\n

\u591a\u304f\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u9031\u306b3\u301c5\u56de\u306e\u4e2d\u7b49\u5ea6\u4ee5\u4e0a\u306e\u6709\u9178\u7d20\u904b\u52d5\uff0830\u5206\u301c1\u6642\u9593\uff09\u304c\u3001\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u3046\u3064\u75c5\u306e\u75c7\u72b6\u3092\u6709\u610f\u306b\u8efd\u6e1b\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u85ac\u7269\u7642\u6cd5\u3068\u306e\u4f75\u7528\u306b\u3088\u308a\u3001\u6cbb\u7642\u52b9\u679c\u304c\u9ad8\u307e\u308b\u30b1\u30fc\u30b9\u3082\u3042\u308b\u3002<\/span><\/p>\n

\u4f8b\u3048\u3070\u3001Blumenthal\u3089\uff081999\uff09\u306e\u7814\u7a76\u3067\u306f\u300112\u9031\u9593\u306e\u904b\u52d5\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u6297\u3046\u3064\u85ac\u3068\u540c\u7b49\u306e\u52b9\u679c\u3092\u793a\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u7279\u306b\u4e2d\u9ad8\u5e74\u8005\u306b\u304a\u3044\u3066\u904b\u52d5\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3092\u5b9f\u8a3c\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

3-2 \u4e0d\u5b89\u969c\u5bb3\u3078\u306e\u52b9\u679c<\/span><\/h3>\n

\u904b\u52d5\u306f\u4e0d\u5b89\u969c\u5bb3\u306b\u3082\u52b9\u679c\u7684\u3067\u3042\u308a\u3001\u7279\u306b\u8eab\u4f53\u7684\u306a\u8208\u596e\u3092\u4f34\u3046\u904b\u52d5\u306f\u4ea4\u611f\u795e\u7d4c\u6d3b\u52d5\u306e\u8abf\u6574\u3084\u904e\u5270\u306a\u899a\u9192\u72b6\u614b\u306e\u7de9\u548c\u306b\u5f79\u7acb\u3064\u3002\u904b\u52d5\u4e2d\u306b\u306fGABA\uff08\u03b3-\u30a2\u30df\u30ce\u916a\u9178\uff09\u3068\u3044\u3046\u6291\u5236\u6027\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u5206\u6ccc\u3082\u9ad8\u307e\u308a\u3001\u3053\u308c\u304c\u4e0d\u5b89\u611f\u306e\u93ae\u9759\u306b\u5bc4\u4e0e\u3059\u308b\u3002<\/span><\/p>\n

3-3 \u8a8d\u77e5\u75c7\u4e88\u9632\u3068\u7cbe\u795e\u7684\u5065\u5eb7<\/span><\/h3>\n

\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u904b\u52d5\u7fd2\u6163\u306f\u3001\u3046\u3064\u75c5\u3060\u3051\u3067\u306a\u304f\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u8efd\u6e1b\u306b\u3082\u3064\u306a\u304c\u308b\u3002BDNF\u306e\u5897\u52a0\u3084\u795e\u7d4c\u65b0\u751f\u306e\u4fc3\u9032\u306b\u3088\u3063\u3066\u3001\u8a18\u61b6\u529b\u3084\u5b9f\u884c\u6a5f\u80fd\u306e\u7dad\u6301\u304c\u671f\u5f85\u3055\u308c\u3001\u3053\u308c\u306f\u81ea\u5df1\u52b9\u529b\u611f\u3084\u793e\u4f1a\u7684\u81ea\u7acb\u306e\u7dad\u6301\u306b\u3082\u8ca2\u732e\u3059\u308b\u3002<\/span><\/p>\n

4. \u5b9f\u8df5\u7684\u5fdc\u7528\u3068\u4eca\u5f8c\u306e\u8ab2\u984c<\/span><\/h2>\n

4-1 \u904b\u52d5\u51e6\u65b9\u306e\u91cd\u8981\u6027<\/span><\/h3>\n

\u52b9\u679c\u7684\u306a\u904b\u52d5\u306b\u3088\u308b\u4ecb\u5165\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u8eab\u4f53\u7684\u80fd\u529b\u3001\u7cbe\u795e\u7684\u72b6\u614b\u306b\u5fdc\u3058\u305f\u300c\u904b\u52d5\u51e6\u65b9\u300d\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002\u500b\u3005\u306e\u30cb\u30fc\u30ba\u306b\u5408\u308f\u305b\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u8a2d\u8a08\u3068\u3001\u52d5\u6a5f\u3065\u3051\u3092\u9ad8\u3081\u308b\u652f\u63f4\u4f53\u5236\u306e\u6574\u5099\u304c\u6c42\u3081\u3089\u308c\u308b\u3002<\/span><\/p>\n

4-2 \u793e\u4f1a\u7684\u8981\u56e0\u3068\u904b\u52d5\u306e\u7d99\u7d9a<\/span><\/h3>\n

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4-3 \u4eca\u5f8c\u306e\u7814\u7a76\u8ab2\u984c<\/span><\/h3>\n

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\u304a\u308f\u308a\u306b<\/span><\/h2>\n

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