{"id":8867,"date":"2025-05-30T21:47:56","date_gmt":"2025-05-30T12:47:56","guid":{"rendered":"https:\/\/kenkoubyouki.com\/?p=8867"},"modified":"2025-05-30T21:47:56","modified_gmt":"2025-05-30T12:47:56","slug":"post-8867","status":"publish","type":"post","link":"https:\/\/kenkoubyouki.com\/?p=8867","title":{"rendered":"\u9577\u5bff\u907a\u4f1d\u5b50\u201c\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u201d\u306e\u6d3b\u6027\u5316\u3068\u5065\u5eb7\u5bff\u547d"},"content":{"rendered":"

\u306f\u3058\u3081\u306b<\/span><\/h2>\n

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\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u3068\u306f\u4f55\u304b<\/span><\/h2>\n

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\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306e\u7814\u7a76\u306e\u7aef\u7dd2\u306f\u30011990\u5e74\u4ee3\u306b\u9175\u6bcd\u306eSir2\u907a\u4f1d\u5b50\u304c\u5bff\u547d\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u767a\u898b\u3055\u308c\u305f\u3053\u3068\u306b\u9061\u308b\u3002Sir2\u306e\u30d2\u30c8\u30db\u30e2\u30ed\u30b0\u3067\u3042\u308bSIRT1\u304c\u6700\u3082\u3088\u304f\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u8001\u5316\u3001\u4ee3\u8b1d\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u3001\u708e\u75c7\u6291\u5236\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u7dad\u6301\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u751f\u547d\u6d3b\u52d5\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306e\u6a5f\u80fd\u3068\u8001\u5316\u306e\u95a2\u4fc2<\/span><\/h2>\n

\u8001\u5316\u306f\u3001DNA\u640d\u50b7\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4f4e\u4e0b\u3001\u6162\u6027\u708e\u75c7\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u6052\u5e38\u6027\u306e\u7834\u7dbb\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306f\u3053\u308c\u3089\u306e\u30d7\u30ed\u30bb\u30b9\u306b\u5bfe\u3057\u3001\u591a\u65b9\u9762\u304b\u3089\u4fdd\u8b77\u7684\u306b\u4f5c\u7528\u3059\u308b\u3002<\/span><\/p>\n

\u305f\u3068\u3048\u3070\u3001SIRT1\u306fp53\u3068\u3044\u3046\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u3092\u5236\u5fa1\u3057\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u7d30\u80de\u6b7b\uff09\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u7d30\u80de\u306e\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3002\u307e\u305f\u3001SIRT3\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u3067\u306e\u6d3b\u6027\u9178\u7d20\u306e\u767a\u751f\u3092\u6291\u3048\u308b\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3057\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7d30\u80de\u3092\u5b88\u308b\u3002SIRT6\u306fDNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3057\u3001\u907a\u4f1d\u5b50\u306e\u5b89\u5b9a\u6027\u3092\u4fdd\u3064\u3053\u3068\u3067\u8001\u5316\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n

\u52d5\u7269\u5b9f\u9a13\u3067\u306f\u3001SIRT1\u3084SIRT6\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u305f\u30de\u30a6\u30b9\u304c\u901a\u5e38\u3088\u308a\u3082\u9577\u5bff\u3067\u3042\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u304c\u8001\u5316\u5236\u5fa1\u306e\u9375\u3092\u63e1\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b9\u6cd5<\/span><\/h2>\n

1. \u30ab\u30ed\u30ea\u30fc\u5236\u9650\uff08Calorie Restriction\uff09<\/span><\/h3>\n

\u6700\u3082\u78ba\u5b9f\u306b\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u3092\u6d3b\u6027\u5316\u3059\u308b\u65b9\u6cd5\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u306e\u304c\u3001\u6442\u53d6\u30ab\u30ed\u30ea\u30fc\u306e\u5236\u9650\u3067\u3042\u308b\u3002\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306f\u3001SIRT1\u306e\u6d3b\u6027\u5316\u3092\u901a\u3058\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306e\u5411\u4e0a\u3001\u708e\u75c7\u306e\u6291\u5236\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b\u306a\u3069\u3001\u6297\u8001\u5316\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u5b9f\u969b\u306b\u3001\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3092\u884c\u3063\u305f\u52d5\u7269\u3067\u306f\u5bff\u547d\u306e\u5ef6\u9577\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u4eba\u9593\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u52b9\u679c\u304c\u3042\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u8b70\u8ad6\u304c\u7d9a\u3044\u3066\u3044\u308b\u3002<\/span><\/p>\n

2. \u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08Resveratrol\uff09<\/span><\/h3>\n

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\u305f\u3060\u3057\u3001\u7d4c\u53e3\u6442\u53d6\u3057\u305f\u5834\u5408\u306e\u4f53\u5185\u3067\u306e\u5b9f\u52b9\u6027\u3084\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u306f\u9650\u5b9a\u7684\u306a\u7814\u7a76\u3057\u304b\u306a\u304f\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u306e\u4f7f\u7528\u306b\u306f\u614e\u91cd\u306a\u691c\u8a0e\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002<\/span><\/p>\n

3. \u30ca\u30a4\u30a2\u30b7\u30f3\uff08\u30d3\u30bf\u30df\u30f3B3\uff09\u8a98\u5c0e\u4f53<\/span><\/h3>\n

\u8fd1\u5e74\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u3001NAD\u207a\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30a2\u30c7\u30cb\u30f3\u30b8\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u3068\u3044\u3046\u88dc\u9175\u7d20\u306e\u524d\u99c6\u4f53\u3067\u3042\u308b\u30ca\u30a4\u30a2\u30b7\u30f3\u8a98\u5c0e\u4f53\uff08NMN\u3084NR\u306a\u3069\uff09\u3067\u3042\u308b\u3002NAD\u207a\u306f\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306e\u6d3b\u6027\u306b\u5fc5\u9808\u306e\u5206\u5b50\u3067\u3042\u308a\u3001\u52a0\u9f62\u3068\u3068\u3082\u306b\u4f53\u5185\u306eNAD\u207a\u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3067\u3001\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u306e\u6a5f\u80fd\u3082\u4f4e\u4e0b\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u3002<\/span><\/p>\n

NMN\uff08\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30e2\u30ce\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u306f\u3001NAD\u207a\u306e\u524d\u99c6\u4f53\u3068\u3057\u3066\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5f62\u3067\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u4f53\u5185\u306eNAD\u207a\u30ec\u30d9\u30eb\u3092\u56de\u5fa9\u3055\u305b\u3001\u7d50\u679c\u3068\u3057\u3066\u30b5\u30fc\u30c1\u30e5\u30a4\u30f3\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13\u3067\u3082\u4e00\u5b9a\u306e\u5b89\u5168\u6027\u3068\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3064\u3064\u3042\u308a\u3001\u4eca\u5f8c\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/span><\/p>\n

4. \u904b\u52d5\u3068\u9069\u5ea6\u306a\u30b9\u30c8\u30ec\u30b9<\/span><\/h3>\n

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    \n
  • \n

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