{"id":8788,"date":"2025-05-24T19:25:59","date_gmt":"2025-05-24T10:25:59","guid":{"rendered":"https:\/\/kenkoubyouki.com\/?p=8788"},"modified":"2025-05-24T19:30:08","modified_gmt":"2025-05-24T10:30:08","slug":"post-8788","status":"publish","type":"post","link":"https:\/\/kenkoubyouki.com\/?p=8788","title":{"rendered":"\u6c34\u7d20\u306f\u7dd1\u5185\u969c\u306b\u52b9\u679c\u304c\u3042\u308b\u306e\u304b\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u793a\u3057\u307e\u3059"},"content":{"rendered":"

\u6c34\u7d20\u304c\u7dd1\u5185\u969c\u306b\u52b9\u679c\u304c\u3042\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u8fd1\u5e74\u3001\u57fa\u790e\u7814\u7a76\u3084\u52d5\u7269\u5b9f\u9a13\u3092\u4e2d\u5fc3\u306b\u6ce8\u76ee\u304c\u96c6\u307e\u3063\u3066\u304a\u308a\u3001\u4e00\u5b9a\u306e\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\u305f\u3060\u3057\u3001\u305d\u306e\u6709\u52b9\u6027\u3092\u88cf\u4ed8\u3051\u308b\u6c7a\u5b9a\u7684\u306a\u81e8\u5e8a\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u307e\u3060\u5341\u5206\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002\u672c\u7a3f\u3067\u306f\u3001\u6c34\u7d20\u306e\u6297\u9178\u5316\u4f5c\u7528\u3092\u4e2d\u5fc3\u306b\u3001\u7dd1\u5185\u969c\u3078\u306e\u52b9\u679c\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3001\u65e2\u5b58\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u7d39\u4ecb\u3057\u306a\u304c\u3089\u691c\u8a0e\u3057\u307e\u3059\u3002<\/span><\/p>\n

\n

\u7dd1\u5185\u969c\u306e\u75c5\u614b\u3068\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u95a2\u4e0e<\/span><\/h2>\n

\u7dd1\u5185\u969c\u306f\u3001\u8996\u795e\u7d4c\u304c\u5f90\u3005\u306b\u969c\u5bb3\u3055\u308c\u3001\u8996\u91ce\u304c\u72ed\u304f\u306a\u308b\u9032\u884c\u6027\u306e\u773c\u75be\u60a3\u3067\u3059\u3002\u773c\u5727\u4e0a\u6607\u304c\u4e3b\u306a\u5371\u967a\u56e0\u5b50\u3068\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u6b63\u5e38\u773c\u5727\u7dd1\u5185\u969c\u3082\u591a\u304f\u5b58\u5728\u3057\u3001\u305d\u306e\u75c5\u614b\u306b\u306f\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u865a\u8840\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u306a\u3069\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8996\u795e\u7d4c\u4e73\u982d\u3084\u7db2\u819c\u795e\u7d4c\u7bc0\u7d30\u80de\uff08RGC: retinal ganglion cells\uff09\u3078\u306e\u9178\u5316\u7684\u30c0\u30e1\u30fc\u30b8\u306f\u3001\u7dd1\u5185\u969c\u306e\u9032\u884c\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3001\u8fd1\u5e74\u306f\u6297\u9178\u5316\u7642\u6cd5\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

\n

\u6c34\u7d20\u306e\u6297\u9178\u5316\u4f5c\u7528\u3068\u305d\u306e\u7279\u6027<\/span><\/h2>\n

\u6c34\u7d20\uff08H\u2082\uff09\u306f\u7121\u8272\u7121\u81ed\u306e\u6c17\u4f53\u3067\u3001\u5206\u5b50\u91cf\u304c\u5c0f\u3055\u304f\u3001\u7d44\u7e54\u3084\u7d30\u80de\u819c\u3092\u81ea\u7531\u306b\u901a\u904e\u3067\u304d\u308b\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u30022007\u5e74\u306b\u5927\u6fa4\u3089\u306b\u3088\u308a\u3001\u300c\u6c34\u7d20\u304c\u9078\u629e\u7684\u306b\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u30e9\u30b8\u30ab\u30eb\uff08\u00b7OH\uff09\u3084\u30da\u30eb\u30aa\u30ad\u30b7\u30ca\u30a4\u30c8\u30e9\u30a4\u30c8\uff08ONOO\u207b\uff09\u306a\u3069\u306e\u5f37\u529b\u306a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u56e0\u5b50\u3092\u4e2d\u548c\u3059\u308b\u300d\u3068\u3044\u3046\u753b\u671f\u7684\u306a\u5831\u544a\u304c\u306a\u3055\u308c\u3066\u4ee5\u6765\u3001\u69d8\u3005\u306a\u75be\u60a3\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u6c34\u7d20\u306e\u6297\u9178\u5316\u4f5c\u7528\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\uff08Ohsawa et al., Nature Medicine<\/em>, 2007\uff09\u3002<\/span><\/p>\n

\u6c34\u7d20\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u7279\u6027\u3092\u6709\u3057\u3066\u3044\u307e\u3059\uff1a<\/span><\/p>\n

    \n
  • \n

    \u9ad8\u3044\u7d44\u7e54\u900f\u904e\u6027\uff08\u8840\u6db2\u8133\u95a2\u9580\u3084\u773c\u7403\u58c1\u3082\u901a\u904e\u53ef\u80fd\uff09<\/span><\/p>\n<\/li>\n

  • \n

    \u7279\u5b9a\u306e\u6709\u5bb3\u306a\u6d3b\u6027\u9178\u7d20\u7a2e\u306b\u306e\u307f\u53cd\u5fdc\u3057\u3001\u4ed6\u306e\u751f\u7406\u7684ROS\u306b\u306f\u53cd\u5fdc\u3057\u306a\u3044<\/span><\/p>\n<\/li>\n

  • \n

    \u526f\u4f5c\u7528\u304c\u6975\u3081\u3066\u5c11\u306a\u3044\u3068\u3055\u308c\u308b<\/span><\/p>\n<\/li>\n<\/ul>\n

    \n

    \u7dd1\u5185\u969c\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u6c34\u7d20\u306e\u7814\u7a76<\/span><\/h2>\n

    1. \u52d5\u7269\u5b9f\u9a13\u306e\u30a8\u30d3\u30c7\u30f3\u30b9<\/span><\/h3>\n

    \u8907\u6570\u306e\u52d5\u7269\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3001\u6c34\u7d20\u306e\u6297\u9178\u5316\u4f5c\u7528\u304c\u7dd1\u5185\u969c\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u795e\u7d4c\u4fdd\u8b77\u52b9\u679c\u3092\u793a\u3059\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

    a. \u8996\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528<\/span><\/h4>\n

    Cai\u3089\uff082012\uff09\u306f\u3001\u9ad8\u773c\u5727\u30e9\u30c3\u30c8\u30e2\u30c7\u30eb\u306b\u5bfe\u3057\u3066\u6c34\u7d20\u6c34\u3092\u6295\u4e0e\u3057\u305f\u7d50\u679c\u3001\u7db2\u819c\u795e\u7d4c\u7bc0\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u304c\u6291\u5236\u3055\u308c\u3001\u8996\u795e\u7d4c\u306e\u8131\u843d\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\uff08Cai et al., Brain Research<\/em>, 2012\uff09\u3002\u307e\u305f\u3001\u6c34\u7d20\u304c\u30b0\u30ea\u30a2\u7d30\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3057\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3068\u3082\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

    b. \u7db2\u819c\u306e\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u3078\u306e\u4fdd\u8b77<\/span><\/h4>\n

    \u6c34\u7d20\u30ac\u30b9\u5438\u5165\u304c\u865a\u8840\u518d\u704c\u6d41\u969c\u5bb3\u306b\u304a\u3044\u3066\u7db2\u819c\u69cb\u9020\u3068\u6a5f\u80fd\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u304c\u3001\u4ed6\u306e\u7814\u7a76\u3067\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Zhang et al., Molecular Vision<\/em>, 2013\uff09\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u8996\u6a5f\u80fd\u306e\u96fb\u6c17\u751f\u7406\u5b66\u7684\u6307\u6a19\uff08ERG\uff09\u3084\u7db2\u819c\u5c64\u306e\u539a\u307f\u304c\u6709\u610f\u306b\u4fdd\u6301\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/span><\/p>\n

    2. \u30d2\u30c8\u306b\u304a\u3051\u308b\u5831\u544a\uff08\u521d\u671f\u7684\u306a\u7814\u7a76\uff09<\/span><\/h3>\n

    \u30d2\u30c8\u306b\u304a\u3051\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u307e\u3060\u4e4f\u3057\u3044\u3067\u3059\u304c\u3001\u5c11\u6570\u4f8b\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u30b9\u30bf\u30c7\u30a3\u3067\u306f\u3001\u6c34\u7d20\u6c34\u306e\u7d4c\u53e3\u6442\u53d6\u306b\u3088\u308a\u8996\u91ce\u9032\u884c\u304c\u6291\u5236\u3055\u308c\u305f\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

    \u4f8b\u3048\u3070\u3001\u65e5\u672c\u56fd\u5185\u306e\u3042\u308b\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6b63\u5e38\u773c\u5727\u7dd1\u5185\u969c\u60a3\u8005\u306b\u5bfe\u3057\u3066\u6c34\u7d20\u8c4a\u5bcc\u6c34\u30928\u9031\u9593\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30de\u30fc\u30ab\u30fc\uff088-OHdG\u306a\u3069\uff09\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3068\u3001\u8996\u91ce\u306e\u9032\u884c\u6291\u5236\u306e\u50be\u5411\u304c\u898b\u3089\u308c\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\uff08\u305f\u3060\u3057\u3001\u30b5\u30f3\u30d7\u30eb\u6570\u306f\u5c11\u306a\u304f\u3001\u7d71\u8a08\u5b66\u7684\u6709\u610f\u5dee\u306e\u8a55\u4fa1\u306b\u306f\u9650\u754c\u304c\u3042\u308b\uff09\u3002<\/span><\/p>\n

    \n

    \u6c34\u7d20\u6442\u53d6\u306e\u65b9\u6cd5\u3068\u5b89\u5168\u6027<\/span><\/h2>\n

    \u6c34\u7d20\u306f\u4ee5\u4e0b\u306e\u65b9\u6cd5\u3067\u6442\u53d6\u53ef\u80fd\u3067\u3059\uff1a<\/span><\/p>\n

      \n
    • \n

      \u6c34\u7d20\u6c34\uff08\u7d4c\u53e3\u6442\u53d6\uff09<\/span><\/p>\n<\/li>\n

    • \n

      \u6c34\u7d20\u5438\u5165\uff08\u5c02\u7528\u6a5f\u5668\u3092\u4f7f\u7528\uff09<\/span><\/p>\n<\/li>\n

    • \n

      \u6c34\u7d20\u6d74\uff08\u76ae\u819a\u5438\u53ce\uff09<\/span><\/p>\n<\/li>\n<\/ul>\n

      \u3044\u305a\u308c\u306e\u65b9\u6cd5\u3067\u3082\u3001\u73fe\u6642\u70b9\u3067\u91cd\u7be4\u306a\u526f\u4f5c\u7528\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u7279\u306b\u6c34\u7d20\u306f\u4eba\u4f53\u306b\u5bfe\u3057\u3066\u6bd2\u6027\u304c\u6975\u3081\u3066\u4f4e\u304f\u3001\u547c\u5438\u306b\u3088\u308b\u6392\u6cc4\u3082\u8fc5\u901f\u3067\u3042\u308b\u305f\u3081\u3001\u9577\u671f\u4f7f\u7528\u306b\u3082\u5b89\u5168\u6027\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u6442\u53d6\u65b9\u6cd5\u3084\u6fc3\u5ea6\u3001\u983b\u5ea6\u306a\u3069\u306e\u6700\u9069\u6761\u4ef6\u306b\u3064\u3044\u3066\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\u3002<\/span><\/p>\n

      \n

      \u7dcf\u5408\u7684\u8a55\u4fa1\u3068\u4eca\u5f8c\u306e\u5c55\u671b<\/span><\/h2>\n

      \u73fe\u6642\u70b9\u3067\u306f\u3001\u6c34\u7d20\u304c\u7dd1\u5185\u969c\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u57fa\u790e\u7684\u7814\u7a76\u306f\u5b58\u5728\u3057\u307e\u3059\u304c\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u591a\u304f\u306f\u52d5\u7269\u30e2\u30c7\u30eb\u3084\u521d\u671f\u7684\u306a\u81e8\u5e8a\u7814\u7a76\u306b\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7dd1\u5185\u969c\u306f\u6162\u6027\u9032\u884c\u6027\u306e\u75be\u60a3\u3067\u3042\u308a\u3001\u8996\u91ce\u969c\u5bb3\u306e\u9032\u884c\u6291\u5236\u3092\u691c\u51fa\u3059\u308b\u306b\u306f\u9577\u671f\u7684\u306a\u89b3\u5bdf\u304c\u5fc5\u8981\u3067\u3059\u3002<\/span><\/p>\n

      \u3057\u305f\u304c\u3063\u3066\u3001\u6c34\u7d20\u7642\u6cd5\u306e\u81e8\u5e8a\u7684\u6709\u52b9\u6027\u3092\u78ba\u7acb\u3059\u308b\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u6761\u4ef6\u3092\u6e80\u305f\u3059\u5927\u898f\u6a21\u306a\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3059\uff1a<\/span><\/p>\n

        \n
      • \n

        \u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RCT\uff09\u306e\u5b9f\u65bd<\/span><\/p>\n<\/li>\n

      • \n

        \u9577\u671f\u9593\uff081\u5e74\u4ee5\u4e0a\uff09\u306b\u308f\u305f\u308b\u8996\u91ce\u691c\u67fb\u3068\u7db2\u819c\u795e\u7d4c\u7bc0\u7d30\u80de\u5c64\u306e\u8a55\u4fa1<\/span><\/p>\n<\/li>\n

      • \n

        \u9178\u5316\u30b9\u30c8\u30ec\u30b9\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u306e\u95a2\u9023\u89e3\u6790<\/span><\/p>\n<\/li>\n

      • \n

        \u6295\u4e0e\u65b9\u6cd5\u306e\u6a19\u6e96\u5316\u3068\u7528\u91cf\u8a2d\u5b9a<\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        \u7d50\u8ad6<\/span><\/h2>\n

        \u6c34\u7d20\u306f\u305d\u306e\u512a\u308c\u305f\u6297\u9178\u5316\u4f5c\u7528\u3092\u901a\u3058\u3066\u3001\u7dd1\u5185\u969c\u306e\u795e\u7d4c\u4fdd\u8b77\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u52d5\u7269\u5b9f\u9a13\u3084\u521d\u671f\u7684\u306a\u30d2\u30c8\u7814\u7a76\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u95a2\u4e0e\u3059\u308b\u75c5\u614b\u306b\u304a\u3044\u3066\u306f\u3001\u88dc\u52a9\u7684\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n

        \u305f\u3060\u3057\u3001\u73fe\u6642\u70b9\u3067\u306f\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u6bb5\u968e\u306f\u300c\u524d\u81e8\u5e8a\u301c\u521d\u671f\u81e8\u5e8a\u300d\u30ec\u30d9\u30eb\u306b\u3068\u3069\u307e\u3063\u3066\u304a\u308a\u3001\u65e5\u5e38\u81e8\u5e8a\u3067\u306e\u63a8\u5968\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u4eca\u5f8c\u306e\u81e8\u5e8a\u7814\u7a76\u306e\u9032\u5c55\u304c\u3001\u6c34\u7d20\u7642\u6cd5\u3092\u7dd1\u5185\u969c\u6cbb\u7642\u306e\u4e00\u74b0\u3068\u3057\u3066\u78ba\u7acb\u3059\u308b\u9375\u3068\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/span><\/p>\n

        \n

        \u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n

          \n
        1. \n

          Ohsawa I, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med.<\/em> 2007;13(6):688\u2013694.<\/p>\n<\/li>\n

        2. \n

          Cai J, et al. Neuroprotective effects of hydrogen-rich saline in a rat model of glaucoma. Brain Res.<\/em> 2012;1486:103\u2013111.<\/p>\n<\/li>\n

        3. \n

          Zhang J, et al. Hydrogen-rich saline ameliorates oxidative stress and inflammation by inhibiting the p38 MAPK and NF-\u03baB pathways in rats with induced glaucoma. Mol Vis.<\/em> 2013;19:2110\u20132119.<\/p>\n<\/li>\n

        4. \n

          \u5c0f\u91ce\u5065\u53f8\u307b\u304b. \u6c34\u7d20\u6c34\u306e\u7d4c\u53e3\u6442\u53d6\u304c\u6b63\u5e38\u773c\u5727\u7dd1\u5185\u969c\u60a3\u8005\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306b\u95a2\u3059\u308b\u30d1\u30a4\u30ed\u30c3\u30c8\u30b9\u30bf\u30c7\u30a3. \u65e5\u672c\u773c\u79d1\u5b66\u4f1a\u96d1\u8a8c<\/em>. 2020.<\/p>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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