{"id":8755,"date":"2025-05-18T16:47:30","date_gmt":"2025-05-18T07:47:30","guid":{"rendered":"https:\/\/kenkoubyouki.com\/?p=8755"},"modified":"2025-05-18T16:47:30","modified_gmt":"2025-05-18T07:47:30","slug":"post-8755","status":"publish","type":"post","link":"https:\/\/kenkoubyouki.com\/?p=8755","title":{"rendered":"\u306a\u305c\u9aa8\u8089\u816b\u304c\u767a\u751f\u3059\u308b\u306e\u304b\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u793a\u3057\u307e\u3059"},"content":{"rendered":"<p class=\"\" data-start=\"0\" data-end=\"203\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\uff08\u3053\u3064\u306b\u304f\u3057\u3085\u3001osteosarcoma\uff09\u306f\u3001\u9aa8\u306e\u60aa\u6027\u816b\u760d\u306e\u4e00\u7a2e\u3067\u3001\u7279\u306b\u6210\u9577\u671f\u306b\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u6210\u4eba\u3067\u3082\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u9aa8\u8089\u816b\u304c\u3069\u306e\u3088\u3046\u306b\u767a\u751f\u3059\u308b\u306e\u304b\u3001\u305d\u3057\u3066\u305d\u306e\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8aac\u660e\u3067\u306f\u3001\u9aa8\u8089\u816b\u306e\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3001\u7d30\u80de\u751f\u7269\u5b66\u7684\u306a\u89b3\u70b9\u3084\u907a\u4f1d\u7684\u8981\u56e0\u3001\u74b0\u5883\u7684\u8981\u56e0\u3001\u3055\u3089\u306b\u306f\u6700\u8fd1\u306e\u7814\u7a76\u7d50\u679c\u3092\u57fa\u306b\u3057\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u793a\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/span><\/p>\n<h3 class=\"\" data-start=\"205\" data-end=\"228\"><span style=\"font-size: 18px;\">1. \u9aa8\u8089\u816b\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0<\/span><\/h3>\n<p class=\"\" data-start=\"230\" data-end=\"344\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306e\u767a\u751f\u306b\u304a\u3044\u3066\u3001\u907a\u4f1d\u7684\u306a\u80cc\u666f\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u591a\u304f\u306e\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u9aa8\u8089\u816b\u306e\u60a3\u8005\u306b\u306f\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u3053\u308c\u304c\u816b\u760d\u5f62\u6210\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u4e3b\u8981\u306a\u907a\u4f1d\u7684\u8981\u56e0\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"346\" data-end=\"362\"><span style=\"font-size: 18px;\">1.1 TP53\u907a\u4f1d\u5b50<\/span><\/h4>\n<p class=\"\" data-start=\"363\" data-end=\"531\"><span style=\"font-size: 18px;\">TP53\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u5468\u671f\u306e\u8abf\u6574\u3084DNA\u4fee\u5fa9\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3001\u764c\u6291\u5236\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002TP53\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u591a\u304f\u306e\u7a2e\u985e\u306e\u764c\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u9aa8\u8089\u816b\u306b\u304a\u3044\u3066\u3082TP53\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u983b\u7e41\u306b\u898b\u3089\u308c\u307e\u3059\u3002TP53\u907a\u4f1d\u5b50\u304c\u640d\u50b7\u3092\u53d7\u3051\u308b\u3068\u3001\u7d30\u80de\u304c\u6b63\u5e38\u306b\u4fee\u5fa9\u3055\u308c\u306a\u304f\u306a\u308a\u3001\u7570\u5e38\u306a\u7d30\u80de\u5206\u88c2\u304c\u9032\u884c\u3059\u308b\u305f\u3081\u3001\u816b\u760d\u304c\u5f62\u6210\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"533\" data-end=\"548\"><span style=\"font-size: 18px;\">1.2 RB1\u907a\u4f1d\u5b50<\/span><\/h4>\n<p class=\"\" data-start=\"549\" data-end=\"678\"><span style=\"font-size: 18px;\">RB1\u907a\u4f1d\u5b50\u306f\u3001\u7d30\u80de\u5468\u671f\u306e\u5236\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u907a\u4f1d\u5b50\u3067\u3001\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u304c\u640d\u50b7\u3092\u53d7\u3051\u308b\u3068\u3001\u7d30\u80de\u5468\u671f\u304c\u7121\u5236\u9650\u306b\u9032\u884c\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u816b\u760d\u5f62\u6210\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u9aa8\u8089\u816b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001RB1\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"680\" data-end=\"696\"><span style=\"font-size: 18px;\">1.3 MDM2\u907a\u4f1d\u5b50<\/span><\/h4>\n<p class=\"\" data-start=\"697\" data-end=\"802\"><span style=\"font-size: 18px;\">MDM2\u907a\u4f1d\u5b50\u306f\u3001TP53\u907a\u4f1d\u5b50\u3092\u6291\u5236\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306e\u904e\u5270\u767a\u73fe\u306fTP53\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3057\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002MDM2\u306e\u904e\u5270\u767a\u73fe\u304c\u9aa8\u8089\u816b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h3 class=\"\" data-start=\"804\" data-end=\"832\"><span style=\"font-size: 18px;\">2. \u9aa8\u8089\u816b\u306e\u767a\u751f\u306b\u304a\u3051\u308b\u7d30\u80de\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0<\/span><\/h3>\n<p class=\"\" data-start=\"834\" data-end=\"981\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306f\u3001\u9aa8\u306e\u4e2d\u306b\u767a\u751f\u3059\u308b\u60aa\u6027\u816b\u760d\u3067\u3059\u304c\u3001\u305d\u306e\u7d30\u80de\u5b66\u7684\u306a\u7279\u5fb4\u3068\u3057\u3066\u3001\u7570\u5e38\u306a\u9aa8\u5f62\u6210\u3092\u4f34\u3046\u3053\u3068\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u3002\u816b\u760d\u7d30\u80de\u306f\u901a\u5e38\u3001\u9aa8\u3092\u5f62\u6210\u3059\u308b\u9aa8\u82bd\u7d30\u80de\u306b\u4f3c\u305f\u7279\u5fb4\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u7d30\u80de\u306f\u7570\u5e38\u306a\u6210\u9577\u3092\u793a\u3057\u3001\u5236\u5fa1\u3055\u308c\u3066\u3044\u306a\u3044\u5897\u6b96\u304c\u7d9a\u304d\u307e\u3059\u3002\u3053\u306e\u7570\u5e38\u306a\u5897\u6b96\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001\u4ee5\u4e0b\u306e\u8981\u56e0\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"983\" data-end=\"999\"><span style=\"font-size: 18px;\">2.1 \u7d30\u80de\u5468\u671f\u306e\u7570\u5e38<\/span><\/h4>\n<p class=\"\" data-start=\"1000\" data-end=\"1121\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306e\u7d30\u80de\u306f\u3001\u901a\u5e38\u306e\u7d30\u80de\u5468\u671f\u306b\u304a\u3051\u308bG1\u671f\u3001S\u671f\u3001G2\u671f\u3001M\u671f\u306e\u8abf\u6574\u304c\u3046\u307e\u304f\u884c\u308f\u308c\u306a\u3044\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u7279\u306b\u3001G1\u671f\u304b\u3089S\u671f\u3078\u306e\u79fb\u884c\u3092\u5236\u5fa1\u3059\u308b\u30b5\u30a4\u30af\u30ea\u30f3D\u3084\u30b5\u30a4\u30af\u30ea\u30f3E\u306e\u904e\u5270\u767a\u73fe\u304c\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"1123\" data-end=\"1142\"><span style=\"font-size: 18px;\">2.2 \u5897\u6b96\u56e0\u5b50\u306e\u904e\u5270\u6d3b\u6027\u5316<\/span><\/h4>\n<p class=\"\" data-start=\"1143\" data-end=\"1274\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u3067\u306f\u3001\u5897\u6b96\u56e0\u5b50\uff08\u7279\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u69d8\u6210\u9577\u56e0\u5b50\u3001IGF\uff09\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u304c\u898b\u3089\u308c\u307e\u3059\u3002IGF\u306f\u3001\u9aa8\u306e\u6210\u9577\u3084\u4fee\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u56e0\u5b50\u3067\u3059\u304c\u3001\u305d\u306e\u904e\u5270\u306a\u767a\u73fe\u306f\u7570\u5e38\u306a\u7d30\u80de\u5897\u6b96\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002IGF\u306e\u53d7\u5bb9\u4f53\u304c\u904e\u5270\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u3067\u3001\u816b\u760d\u7d30\u80de\u306f\u7121\u5236\u9650\u306b\u5897\u6b96\u3057\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"1276\" data-end=\"1289\"><span style=\"font-size: 18px;\">2.3 \u8840\u7ba1\u65b0\u751f<\/span><\/h4>\n<p class=\"\" data-start=\"1290\" data-end=\"1395\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306f\u3001\u9ad8\u3044\u8840\u7ba1\u65b0\u751f\uff08\u65b0\u3057\u3044\u8840\u7ba1\u306e\u5f62\u6210\uff09\u3092\u4f34\u3046\u816b\u760d\u3067\u3059\u3002\u816b\u760d\u306e\u6210\u9577\u3092\u652f\u3048\u308b\u305f\u3081\u306b\u3001\u816b\u760d\u5185\u3067\u8840\u7ba1\u304c\u65b0\u305f\u306b\u4f5c\u3089\u308c\u308b\u73fe\u8c61\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u8840\u7ba1\u65b0\u751f\u306f\u3001\u816b\u760d\u306e\u6804\u990a\u4f9b\u7d66\u3092\u78ba\u4fdd\u3057\u3001\u816b\u760d\u304c\u62e1\u5927\u3059\u308b\u305f\u3081\u306e\u6761\u4ef6\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/span><\/p>\n<h3 class=\"\" data-start=\"1397\" data-end=\"1419\"><span style=\"font-size: 18px;\">3. \u9aa8\u8089\u816b\u306e\u767a\u751f\u306b\u304a\u3051\u308b\u74b0\u5883\u7684\u8981\u56e0<\/span><\/h3>\n<p class=\"\" data-start=\"1421\" data-end=\"1483\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306e\u767a\u751f\u306b\u304a\u3044\u3066\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u5883\u7684\u8981\u56e0\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u4ee5\u4e0b\u306e\u8981\u56e0\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"1485\" data-end=\"1499\"><span style=\"font-size: 18px;\">3.1 \u653e\u5c04\u7dda\u66dd\u9732<\/span><\/h4>\n<p class=\"\" data-start=\"1500\" data-end=\"1612\"><span style=\"font-size: 18px;\">\u653e\u5c04\u7dda\u306f\u3001DNA\u306b\u640d\u50b7\u3092\u4e0e\u3048\u308b\u305f\u3081\u3001\u764c\u306e\u767a\u751f\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u9aa8\u8089\u816b\u306f\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u653e\u5c04\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u304c\u3001\u9aa8\u8089\u816b\u306e\u767a\u751f\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"1614\" data-end=\"1628\"><span style=\"font-size: 18px;\">3.2 \u5916\u7684\u306a\u5916\u50b7<\/span><\/h4>\n<p class=\"\" data-start=\"1629\" data-end=\"1742\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306f\u3057\u3070\u3057\u3070\u9aa8\u6298\u3084\u5916\u50b7\u3092\u53d7\u3051\u305f\u90e8\u4f4d\u306b\u767a\u75c7\u3057\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u5358\u306b\u9aa8\u6298\u5f8c\u306e\u7d30\u80de\u306e\u4fee\u5fa9\u904e\u7a0b\u3067\u7570\u5e38\u304c\u751f\u3058\u308b\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5916\u7684\u306a\u523a\u6fc0\u304c\u7d30\u80de\u306e\u518d\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u4e71\u3057\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<h3 class=\"\" data-start=\"1744\" data-end=\"1765\"><span style=\"font-size: 18px;\">4. \u9aa8\u8089\u816b\u306e\u767a\u751f\u306b\u304a\u3051\u308b\u514d\u75ab\u5fdc\u7b54<\/span><\/h3>\n<p class=\"\" data-start=\"1767\" data-end=\"1873\"><span style=\"font-size: 18px;\">\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u9aa8\u8089\u816b\u306b\u304a\u3051\u308b\u514d\u75ab\u5fdc\u7b54\u304c\u816b\u760d\u306e\u9032\u884c\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u514d\u75ab\u7cfb\u306f\u3001\u304c\u3093\u7d30\u80de\u3092\u8b58\u5225\u3057\u653b\u6483\u3059\u308b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u304c\u3001\u9aa8\u8089\u816b\u3067\u306f\u514d\u75ab\u7d30\u80de\u304c\u816b\u760d\u7d30\u80de\u3092\u5341\u5206\u306b\u6392\u9664\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"1875\" data-end=\"1888\"><span style=\"font-size: 18px;\">4.1 \u514d\u75ab\u9003\u907f<\/span><\/h4>\n<p class=\"\" data-start=\"1889\" data-end=\"2011\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306e\u816b\u760d\u7d30\u80de\u306f\u3001\u514d\u75ab\u7cfb\u304b\u3089\u9003\u907f\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u816b\u760d\u7d30\u80de\u306f\u514d\u75ab\u6291\u5236\u56e0\u5b50\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u3067\u3001\u5468\u56f2\u306e\u514d\u75ab\u7d30\u80de\u304c\u816b\u760d\u3092\u653b\u6483\u3059\u308b\u306e\u3092\u9632\u3050\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u514d\u75ab\u9003\u907f\u306f\u3001\u9aa8\u8089\u816b\u304c\u9032\u884c\u3059\u308b\u4e00\u56e0\u3068\u3057\u3066\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h4 class=\"\" data-start=\"2013\" data-end=\"2024\"><span style=\"font-size: 18px;\">4.2 \u708e\u75c7<\/span><\/h4>\n<p class=\"\" data-start=\"2025\" data-end=\"2125\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306f\u6162\u6027\u7684\u306a\u708e\u75c7\u72b6\u614b\u3092\u4f34\u3046\u3053\u3068\u304c\u591a\u304f\u3001\u708e\u75c7\u53cd\u5fdc\u304c\u816b\u760d\u306e\u767a\u751f\u3084\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u708e\u75c7\u304c\u6301\u7d9a\u3059\u308b\u3068\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u6210\u9577\u56e0\u5b50\u304c\u5206\u6ccc\u3055\u308c\u3001\u3053\u308c\u304c\u816b\u760d\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<h3 class=\"\" data-start=\"2127\" data-end=\"2145\"><span style=\"font-size: 18px;\">5. \u6700\u8fd1\u306e\u7814\u7a76\u3068\u6cbb\u7642\u306e\u9032\u5c55<\/span><\/h3>\n<p class=\"\" data-start=\"2147\" data-end=\"2274\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306e\u6cbb\u7642\u306b\u306f\u3001\u624b\u8853\u3001\u5316\u5b66\u7642\u6cd5\u3001\u653e\u5c04\u7dda\u6cbb\u7642\u304c\u4e00\u822c\u7684\u306b\u884c\u308f\u308c\u307e\u3059\u304c\u3001\u6cbb\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001\u9aa8\u8089\u816b\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u305f\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u514d\u75ab\u7642\u6cd5\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u304c\u6709\u671b\u306a\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p class=\"\" data-start=\"2276\" data-end=\"2343\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306e\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u7814\u7a76\u306f\u4eca\u5f8c\u3082\u9032\u5c55\u304c\u671f\u5f85\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u5c0e\u5165\u304c\u3001\u60a3\u8005\u306e\u4e88\u5f8c\u6539\u5584\u306b\u7e4b\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n<h3 class=\"\" data-start=\"2345\" data-end=\"2354\"><span style=\"font-size: 18px;\">6. \u7d50\u8ad6<\/span><\/h3>\n<p class=\"\" data-start=\"2356\" data-end=\"2500\"><span style=\"font-size: 18px;\">\u9aa8\u8089\u816b\u306f\u3001\u591a\u304f\u306e\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u767a\u751f\u3059\u308b\u75c5\u6c17\u3067\u3059\u3002\u907a\u4f1d\u7684\u8981\u56e0\u3001\u7d30\u80de\u751f\u7269\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3001\u74b0\u5883\u7684\u8981\u56e0\u3001\u514d\u75ab\u5fdc\u7b54\u306a\u3069\u304c\u95a2\u4e0e\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u304c\u76f8\u4e92\u306b\u4f5c\u7528\u3057\u3066\u816b\u760d\u306e\u767a\u751f\u3068\u9032\u884c\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u4eca\u5f8c\u306e\u7814\u7a76\u304c\u9032\u3080\u3053\u3068\u3067\u3001\u3088\u308a\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3001\u9aa8\u8089\u816b\u306e\u4e88\u9632\u3084\u6cbb\u7642\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671b\u307e\u308c\u307e\u3059\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9aa8\u8089\u816b\uff08\u3053\u3064\u306b\u304f\u3057\u3085\u3001osteosarcoma\uff09\u306f\u3001\u9aa8\u306e\u60aa\u6027\u816b\u760d\u306e\u4e00\u7a2e\u3067\u3001\u7279\u306b\u6210\u9577\u671f\u306b\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u304c\u3001\u6210\u4eba\u3067\u3082\u767a\u751f\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u9aa8\u8089\u816b\u304c\u3069\u306e\u3088\u3046\u306b\u767a\u751f\u3059\u308b\u306e\u304b\u3001\u305d\u3057\u3066\u305d\u306e\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u8981\u56e0\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8aac\u660e\u3067\u306f\u3001\u9aa8\u8089\u816b\u306e\u767a\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3001\u7d30\u80de\u751f\u7269\u5b66\u7684\u306a\u89b3\u70b9\u3084\u907a\u4f1d\u7684\u8981\u56e0\u3001\u74b0\u5883\u7684\u8981\u56e0\u3001\u3055\u3089\u306b\u306f\u6700\u8fd1\u306e\u7814\u7a76\u7d50\u679c\u3092\u57fa\u306b\u3057\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u793a\u3057\u3066\u3044\u304d\u307e\u3059\u3002 1. 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